The accident was one of a rash of collisions and rollovers that occurred after rain, sleet and snow made travel hazardous across the county Thursday.
Smyer firefighters responded to Thursday’s fatality shortly after 9 a.m.
The driver of a Ford F-150 pickup, 34-year-old Francisco Alvizo, died at the scene.
The occupants of the second vehicle were pulled from it by three men, said State Trooper Pete Ramos.
The accident occurred at 9:17 a.m., less than a mile west of Smyer.
Christopher Castillo, 20, of Lubbock was headed west when he lost control of his Ford Ranger pickup truck.
The truck veered into the center median and entered the eastbound lanes, colliding head-on with Alvizo’s vehicle.